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A compact light-sheet microscope for the study of the mammalian central nervous system

Abstract:

Investigation of the transient processes integral to neuronal function demands rapid and high-resolution imaging techniques over a large field of view, which cannot be achieved with conventional scanning microscopes. Here we describe a compact light sheet fluorescence microscope, featuring a 45° inverted geometry and an integrated photolysis laser, that is optimized for applications in neuroscience, in particular fast imaging of sub-neuronal structures in mammalian brain slices. We demonstrat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep26317

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Biotechnology and Biological Sciences Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Article number:
26317
Publication date:
2016-04-01
Acceptance date:
2016-04-07
DOI:
ISSN:
2045-2322
Source identifiers:
615291
Pubs id:
pubs:615291
UUID:
uuid:fb0936cf-566b-4d86-9c06-7794b3d0aaec
Local pid:
pubs:615291
Deposit date:
2016-04-14

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