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Interaction between familial transmission and a constitutively active immune system shapes gut microbiota in Drosophila melanogaster.

Abstract:

Resident gut bacteria are constantly influencing the immune system. Yet the role of the immune system in shaping microbiota composition during an organism's lifespan has remained unclear. Experiments in mice have been inconclusive due to differences in husbandry schemes that led to conflicting results. We used Drosophila as a genetically tractable system with simpler gut bacterial population structure and streamlined genetic backgrounds and established cross schemes to address this issue. We ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1534/genetics.116.190215

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Department:
Oxford, MSD, Biochemistry
Role:
Author
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Department:
St Cross College
Role:
Author
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Funding agency for:
Ligoxygakis, P
Publisher:
Genetics Society of America Publisher's website
Journal:
Genetics Journal website
Volume:
206
Issue:
2
Pages:
889-904
Publication date:
2017-06-05
Acceptance date:
2017-03-31
DOI:
EISSN:
1943-2631
ISSN:
0016-6731
Pubs id:
pubs:690758
URN:
uri:fb001e2e-3cff-4ede-8c67-c4931893fd29
UUID:
uuid:fb001e2e-3cff-4ede-8c67-c4931893fd29
Local pid:
pubs:690758

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