- Abstract:
-
Sulfadoxine/pyrimethamine with amodiaquine is recommended by the World Health Organization as seasonal malaria chemoprevention for children between 3 to 59 months in the sub-Sahel regions of Africa. Sub-optimal dosing in children may lead to treatment failure and increased resistance. Pooled individual patient data from four previously published trials on the pharmacokinetics of sulfadoxine and pyrimethamine in 415 paediatric and 386 adult patients were analysed using nonlinear mixed effects ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.4MB)
-
- Publisher copy:
- 10.1128/aac.01370-17
-
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- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Antimicrobial Agents and Chemotherapy Journal website
- Volume:
- 62
- Issue:
- 5
- Pages:
- Article: e0137017
- Publication date:
- 2018-02-20
- Acceptance date:
- 2018-02-10
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- Pubs id:
-
pubs:826847
- URN:
-
uri:faff2595-fe34-40b7-8504-16a8ea7ba38f
- UUID:
-
uuid:faff2595-fe34-40b7-8504-16a8ea7ba38f
- Local pid:
- pubs:826847
- Language:
- English
- Keywords:
- Copyright holder:
- © 2018 de Kock et al.
- Copyright date:
- 2018
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Journal article
Population pharmacokinetic properties of sulfadoxine and pyrimethamine: a pooled analysis to inform optimal dosing in African children with uncomplicated malaria
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