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Population pharmacokinetic properties of sulfadoxine and pyrimethamine: a pooled analysis to inform optimal dosing in African children with uncomplicated malaria

Abstract:

Sulfadoxine/pyrimethamine with amodiaquine is recommended by the World Health Organization as seasonal malaria chemoprevention for children between 3 to 59 months in the sub-Sahel regions of Africa. Sub-optimal dosing in children may lead to treatment failure and increased resistance. Pooled individual patient data from four previously published trials on the pharmacokinetics of sulfadoxine and pyrimethamine in 415 paediatric and 386 adult patients were analysed using nonlinear mixed effects ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.01370-17

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Role:
Author
ORCID:
0000-0003-4566-4030
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
5
Pages:
Article: e0137017
Publication date:
2018-02-20
Acceptance date:
2018-02-10
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:826847
URN:
uri:faff2595-fe34-40b7-8504-16a8ea7ba38f
UUID:
uuid:faff2595-fe34-40b7-8504-16a8ea7ba38f
Local pid:
pubs:826847
Language:
English
Keywords:

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