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Prospective identification of malaria parasite genes under balancing selection.

Abstract:

BACKGROUND: Endemic human pathogens are subject to strong immune selection, and interrogation of pathogen genome variation for signatures of balancing selection can identify important target antigens. Several major antigen genes in the malaria parasite Plasmodium falciparum have shown such signatures in polymorphism-versus-divergence indices (comparing with the chimpanzee parasite P. reichenowi), and in allele frequency based indices. METHODOLOGY/PRINCIPAL FINDINGS: To compare methods for pro...

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10.1371/journal.pone.0005568

Authors


Tetteh, KK More by this author
Stewart, LB More by this author
Ochola, LI More by this author
Amambua-Ngwa, A More by this author
Thomas, AW More by this author
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Journal:
PloS one
Volume:
4
Issue:
5
Pages:
e5568
Publication date:
2009
DOI:
EISSN:
1932-6203
URN:
uuid:fafeb6b1-b25e-4651-8648-137436ac1b73
Source identifiers:
184991
Local pid:
pubs:184991

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