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CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry.

Abstract:

Most vertebrate and plant RNA and small DNA viruses suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking host mRNA composition. Artificially increasing CpG/UpA dinucleotides attenuates viruses through an entirely unknown mechanism. Using the echovirus 7 (E7) model in several cell types, we show that the restriction in E7 replication in mutants with increased CpG/UpA dinucleotides occurred immediately after viral entry, with incoming virions failing to form replication c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/elife.29112

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Passchier, TC More by this author
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Publisher:
eLife Sciences Publisher's website
Journal:
eLife Journal website
Volume:
6
Pages:
e29112
Publication date:
2017-09-05
Acceptance date:
2017-09-28
DOI:
EISSN:
2050-084X
Pubs id:
pubs:732044
URN:
uri:fafdfc6f-2a42-4b22-8102-510f1e36bb91
UUID:
uuid:fafdfc6f-2a42-4b22-8102-510f1e36bb91
Local pid:
pubs:732044
Language:
English
Keywords:

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