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Journal article

Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse.

Abstract:

Cell-to-cell transmission of human immunodeficiency virus type 1 (HIV-1) occurs via a virological synapse (VS), a tight cell-cell junction formed between HIV-infected cells and target cells in which the HIV-1-infected cell polarizes and releases virions toward the noninfected target cell in a gp120- and intercellular adhesion molecule 1 (ICAM-1)-dependent process. The response of the target cell has been less studied. We utilized supported planar bilayers presenting gp120 and ICAM-1 as a redu...

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Publisher copy:
10.1128/jvi.01440-09

Authors


Vasiliver-Shamis, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Journal of virology
Volume:
83
Issue:
21
Pages:
11341-11355
Publication date:
2009-11-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:faf855a7-02a2-484d-962e-9e4a696c00bd
Source identifiers:
426291
Local pid:
pubs:426291

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