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Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12.

Abstract:

Crohn's disease (CD) and ulcerative colitis (UC), the chronic inflammatory bowel diseases (CIBD), are common causes of gastro-intestinal disease in the Western world, with a combined prevalence of 100-200/100,000 (ref. 1). Epidemiological studies, particularly concordance rates in twin pairs and siblings, strongly implicate genetic susceptibility in the pathogenesis of CIBD. In fact, the relative contribution of genetic factors to the pathogenesis of CD may be greater than in schizophrenia, a...

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Publication status:
Published

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Publisher copy:
10.1038/ng1096-199

Authors


Satsangi, J More by this author
Hashimoto, L More by this author
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Journal:
Nature genetics
Volume:
14
Issue:
2
Pages:
199-202
Publication date:
1996-10-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:faf43b91-1167-4b92-934b-921544903df1
Source identifiers:
135430
Local pid:
pubs:135430

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