Defining childhood severe falciparum malaria for intervention studies
Background: Clinical trials of interventions designed to prevent severe falciparum malaria in children require a clear endpoint. The internationally accepted definition of severe malaria is sensitive, and appropriate for clinical purposes. However, this definition includes individuals with severe nonmalarial disease and coincident parasitaemia, so may lack specificity in vaccine trials. Although there is no ‘‘gold standard’’ individual test for severe malaria, malaria-attributable fractions (...Expand abstract
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- Bejon et al.
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- Citation: Bejon, P. et al. (2007). 'Defining childhood severe falciparum malaria for intervention studies', PLoS Medicine, 4(8), e251. [Available at http://www.plosmedicine.org]. © 2007 Bejon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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