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Amplification of natural regulatory immune mechanisms for transplantation tolerance.

Abstract:

There is a need to derive donor-specific tolerance in clinical organ transplantation, where potential benefits remain overshadowed by chronic rejection and side effects of continual immunosuppressive therapy. It is known that the mature immune system in mice can be reprogrammed to accept a foreign graft as if it were "self." Here we show that, once generated, this state of operational tolerance becomes self-sustaining, imposing itself on new cohorts of lymphocytes as they arise. These new coh...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Transplantation More from this journal
Volume:
62
Issue:
9
Pages:
1200-1206
Publication date:
1996-11-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337

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