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Mortality and cancer incidence in persons with Down's syndrome, their parents and siblings.

Abstract:

A cohort study of 1425 persons with Down's syndrome (DS), and of their parents (447 mothers, 435 fathers) and siblings (1176), was set up to investigate death rates from various causes and cancer incidence patterns. In individuals with DS the all-cause death rate was six times that of the national population (SMR = 622: 95% CI 559-693), the excess being attributable to many different causes. These included: leukaemia (SMR = 1304: 95% CI 651-2334); diabetes mellitus (SMR = 982: 95% CI 267-2515...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
Journal:
Annals of human genetics More from this journal
Volume:
65
Issue:
Pt 2
Pages:
167-176
Publication date:
2001-03-01
DOI:
EISSN:
1469-1809
ISSN:
0003-4800
Language:
English
Keywords:
Pubs id:
pubs:31904
UUID:
uuid:fae4e35b-24a1-4a20-9865-0c5d0840208f
Local pid:
pubs:31904
Source identifiers:
31904
Deposit date:
2012-12-19

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