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Multivalent recombinant proteins for probing functions of leucocyte surface proteins such as the CD200 receptor.

Abstract:

CD200 (OX2) is a membrane glycoprotein that interacts with a structurally related receptor (CD200R) involved in the regulation of macrophage function. The interaction is of low affinity (K(D) approximately 1 microm) but can be detected using CD200 displayed in a multivalent form on beads or with dimeric fusion proteins consisting of the extracellular region of CD200 and immunoglobulin Fc regions. We prepared putative pentamers and trimers of mouse CD200 with sequences from cartilage oligomeri...

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Publication status:
Published

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Journal:
Immunology More from this journal
Volume:
115
Issue:
3
Pages:
337-346
Publication date:
2005-07-01
DOI:
EISSN:
1365-2567
ISSN:
0019-2805

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