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Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease.

Abstract:

Lipids such as ceramides (Cer) and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3233/JAD-160645

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Name:
European Union
Grant:
FP7 2007-2013) ADAMS project, HEALTH-F4-2009-242257
Publisher:
IOS Press
Journal:
Journal of Alzheimer's Disease More from this journal
Volume:
60
Issue:
3
Pages:
809-817
Publication date:
2016-11-26
Acceptance date:
2016-10-04
DOI:
EISSN:
1875-8908
ISSN:
1387-2877
Language:
English
Keywords:
Pubs id:
pubs:664093
UUID:
uuid:fae1b5c7-9002-40da-b83b-e2db75307309
Local pid:
pubs:664093
Source identifiers:
664093
Deposit date:
2017-04-12

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