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Tracking the establishment of local endemic populations of an emergent enteric pathogen.

Abstract:

Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and conv...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1308632110

Authors


Thieu Nga, TV More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
43
Pages:
17522-17527
Publication date:
2013-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:fadf932d-14d6-4dfd-a66c-26226fae0f4a
Source identifiers:
431343
Local pid:
pubs:431343

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