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NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts

Abstract:

The transcription factor NF-κB is of major importance in the biology of pro-inflammatory cytokines, such as TNF-α and IL-1α, and thereby is intimately involved in the process of inflammation. Understanding the mechanisms by which NF-κB is activated in response to inflammatory stimuli has become a major goal of inflammation research. The discovery of NF-κB-inducing kinase (NIK) as a TNFR-associated factor-interacting enzyme and a potential activator of the IκBα-kinase complex appeared to have ...

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Authors


Andreakos, E More by this author
Crawley, JB More by this author
Brennan, FM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Journal of Immunology
Volume:
167
Issue:
10
Pages:
5895-5903
Publication date:
2001-11-15
ISSN:
0022-1767
URN:
uuid:fadd6e16-8683-4f30-8375-1c597d4127e1
Source identifiers:
225743
Local pid:
pubs:225743
Language:
English

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