Journal article icon

Journal article

A serpin mutant links Toll activation to melanization in the host defence of Drosophila.

Abstract:

A prominent response during the Drosophila host defence is the induction of proteolytic cascades, some of which lead to localized melanization of pathogen surfaces, while others activate one of the major players in the systemic antimicrobial response, the Toll pathway. Despite the fact that gain-of-function mutations in the Toll receptor gene result in melanization, a clear link between Toll activation and the melanization reaction has not been firmly established. Here, we present evidence fo...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/emboj/cdf661

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Leclerc, V More by this author
Expand authors...
Journal:
The EMBO journal
Volume:
21
Issue:
23
Pages:
6330-6337
Publication date:
2002-12-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:fadaa212-a630-4e3e-bd44-5af882d12519
Source identifiers:
99901
Local pid:
pubs:99901

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP