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The size of sites containing SR proteins in human nuclei. Problems associated with characterizing small structures by immunogold labeling.

Abstract:

Some SR proteins are associated with eukaryotic transcripts as they move from synthetic sites (transcription "factories"), through downstream sites, to nuclear pores. Downstream sites can also be isolated as large nuclear ribonucleoprotein particles of approximately 200 S (diameter approximately 50 nm). In ultrathin sections of HeLa nuclei, indirect immunogold labeling with a specific antibody gives many small clusters of approximately 10 gold particles (diameter 50-80 nm). We gauged errors i...

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Publication status:
Published

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Publisher copy:
10.1177/002215549804600901

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
journal of histochemistry and cytochemistry : official journal of the Histochemistry Society More from this journal
Volume:
46
Issue:
9
Pages:
985-992
Publication date:
1998-09-01
DOI:
EISSN:
1551-5044
ISSN:
0022-1554
Language:
English
Keywords:
Pubs id:
pubs:22920
UUID:
uuid:fada4e15-0060-4f42-ad5f-c13fdb415911
Local pid:
pubs:22920
Source identifiers:
22920
Deposit date:
2012-12-19

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