Journal article
Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation.
- Abstract:
-
Osteoclast formation in bone is supported by osteoblasts expressing receptor activator of NF-kappa B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) expression. Numerous osteotropic factors regulate expression levels of RANKL and the RANKL decoy receptor osteoprotegerin (OPG) in osteoblasts, thereby affecting osteoclast differentiation. However, not only in RANKL widely expressed in soft tissues, but osteoclasts have been noted in extraskeletal lesions. We found that cultured ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1359/jbmr.2000.15.8.1459
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Bibliographic Details
- Journal:
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- Volume:
- 15
- Issue:
- 8
- Pages:
- 1459-1466
- Publication date:
- 2000-08-01
- DOI:
- EISSN:
-
1523-4681
- ISSN:
-
0884-0431
- Source identifiers:
-
223477
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:223477
- UUID:
-
uuid:fac7eb52-d171-46e7-b371-1a263a63cbf3
- Local pid:
- pubs:223477
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2000
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