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Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation.

Abstract:

Osteoclast formation in bone is supported by osteoblasts expressing receptor activator of NF-kappa B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) expression. Numerous osteotropic factors regulate expression levels of RANKL and the RANKL decoy receptor osteoprotegerin (OPG) in osteoblasts, thereby affecting osteoclast differentiation. However, not only in RANKL widely expressed in soft tissues, but osteoclasts have been noted in extraskeletal lesions. We found that cultured ...

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Publication status:
Published

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Publisher copy:
10.1359/jbmr.2000.15.8.1459

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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
15
Issue:
8
Pages:
1459-1466
Publication date:
2000-08-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:fac7eb52-d171-46e7-b371-1a263a63cbf3
Source identifiers:
223477
Local pid:
pubs:223477

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