Journal article
Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer
- Abstract:
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While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationship between lipid traits and CRC risk. We used single nucleotide polymorphisms (SNPs) associated with blood levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) as instrumental variab...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 1.0MB)
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- Publisher copy:
- 10.1002/ijc.30709
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Authors
Funding
Oxford Comprehensive Biomedical Research Centre
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- International Journal of Cancer Journal website
- Volume:
- 140
- Issue:
- 12
- Pages:
- 2701-2708
- Publication date:
- 2017-03-24
- Acceptance date:
- 2017-02-08
- DOI:
- EISSN:
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1097-0215
- ISSN:
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0020-7136
- Source identifiers:
-
687170
Item Description
- Keywords:
- Pubs id:
-
pubs:687170
- UUID:
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uuid:fac7b2b4-e22c-4eae-8652-00cb59e79b83
- Local pid:
- pubs:687170
- Deposit date:
- 2017-03-27
Terms of use
- Copyright holder:
- © 2017 UICC
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Wiley at: 10.1002/ijc.30709
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