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Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

Abstract:

While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationship between lipid traits and CRC risk. We used single nucleotide polymorphisms (SNPs) associated with blood levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) as instrumental variab...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/ijc.30709

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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Grant:
C1298/A8362 - Bobby Moore Fund for Cancer Research UK
Oxford Comprehensive Biomedical Research Centre More from this funder
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Publisher:
Wiley Publisher's website
Journal:
International Journal of Cancer Journal website
Volume:
140
Issue:
12
Pages:
2701-2708
Publication date:
2017-03-24
Acceptance date:
2017-02-08
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Pubs id:
pubs:687170
URN:
uri:fac7b2b4-e22c-4eae-8652-00cb59e79b83
UUID:
uuid:fac7b2b4-e22c-4eae-8652-00cb59e79b83
Local pid:
pubs:687170
Paper number:
12

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