- Abstract:
-
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationship between lipid traits and CRC risk. We used single nucleotide polymorphisms (SNPs) associated with blood levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) as instrumental variab...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 1.0MB)
-
- Publisher copy:
- 10.1002/ijc.30709
-
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- Grant:
- C1298/A8362 - Bobby Moore Fund for Cancer Research UK
- Publisher:
- Wiley Publisher's website
- Journal:
- International Journal of Cancer Journal website
- Volume:
- 140
- Issue:
- 12
- Pages:
- 2701-2708
- Publication date:
- 2017-03-24
- Acceptance date:
- 2017-02-08
- DOI:
- EISSN:
-
1097-0215
- ISSN:
-
0020-7136
- Pubs id:
-
pubs:687170
- URN:
-
uri:fac7b2b4-e22c-4eae-8652-00cb59e79b83
- UUID:
-
uuid:fac7b2b4-e22c-4eae-8652-00cb59e79b83
- Local pid:
- pubs:687170
- Paper number:
- 12
- Copyright holder:
- © 2017 UICC
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Wiley at: 10.1002/ijc.30709
- License:
- CC BY-NC-SA
Journal article
Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer
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