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Journal article

Cohesin: its roles and mechanisms.

Abstract:
The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.
Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Annual review of genetics More from this journal
Volume:
43
Issue:
1
Pages:
525-558
Publication date:
2009-01-01
DOI:
EISSN:
1545-2948
ISSN:
0066-4197
Language:
English
Keywords:
Pubs id:
pubs:98425
UUID:
uuid:fabb975b-0634-496c-86a6-ae10ee0913e5
Local pid:
pubs:98425
Source identifiers:
98425
Deposit date:
2012-12-19

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