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Distinct immune responses and virus shedding in pigs following aerosol, intra-nasal and contact infection with pandemic swine influenza A virus, A(H1N1)09

Abstract:

Influenza virus infection in pigs is a major farming problem, causing considerable economic loss and posing a zoonotic threat. In addition the pig is an excellent model for understanding immunity to influenza viruses as this is a natural host pathogen system. Experimentally, influenza virus is delivered to pigs intra-nasally, by intra-tracheal instillation or by aerosol, but there is little data comparing the outcome of different methods. We evaluated the shedding pattern, cytokine responses ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13567-016-0390-5

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
Veterinary Research Journal website
Volume:
47
Issue:
1
Pages:
103
Publication date:
2016-10-20
Acceptance date:
2016-09-30
DOI:
EISSN:
1297-9716
ISSN:
0928-4249
Pubs id:
pubs:655177
URN:
uri:fab5b129-fec9-43c1-bed9-6413d812c56d
UUID:
uuid:fab5b129-fec9-43c1-bed9-6413d812c56d
Local pid:
pubs:655177

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