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Journal article

The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity.

Abstract:

Immunoglobulin A (IgA) secretion by plasma cells in the immune system is critical for protecting the host from environmental and microbial infections. However, the molecular mechanisms underlying the generation of IgA(+) plasma cells remain poorly understood. Here, we report that the B cell-expressed tetraspanin CD37 inhibits IgA immune responses in vivo. CD37-deficient (CD37-/-) mice exhibit a 15-fold increased level of IgA in serum and significantly elevated numbers of IgA(+) plasma cells i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1000338

Authors


van Spriel, AB More by this author
Gartlan, KH More by this author
van der Schaaf, A More by this author
Verschueren, I More by this author
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Dutch Cancer Society More from this funder
Netherlands Organization for Scientific Research More from this funder
Association of International Cancer Research More from this funder
Australian National Health and Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLOS PATHOGENS Journal website
Volume:
5
Issue:
3
Pages:
e1000338
Publication date:
2009-03-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:fab51ab3-0ce0-4040-8308-92f5eba2331d
Source identifiers:
60433
Local pid:
pubs:60433

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