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Short-term hypocaloric nutrition but not bed rest decrease insulin sensitivity and IGF-I bioavailability in healthy subjects: the importance of glucagon.

Abstract:

Hyperinsulinemic, normoglycemic clamps were performed before and after 24 h of either hypocaloric nutrition or bed rest in healthy subjects. Decreased insulin sensitivity and insulin-like growth factor-I (IGF-I) bioavalibility, as measured by the serum IGF-I/insulin-like growth factor binding protein-1 (IGFBP-1) ratio, was found after fasting, whereas no metabolic changes were found after bed rest. Glucagon seems to be a key regulator of IGFBP-1 after brief hypocaloric nutrition. Hypocaloric ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Nutrition (Burbank, Los Angeles County, Calif.) More from this journal
Volume:
13
Issue:
11-12
Pages:
945-951
Publication date:
1997-01-01
Event title:
18th Congress of the European-Society-of-Enteral-and-Parenteral-Nutrition
DOI:
EISSN:
1873-1244
ISSN:
0899-9007

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