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Journal article

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Abstract:

Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United Kingdom healthcare workers. The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. In a substudy of 589 individuals, we show that this single dose induces severe acute respiratory...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2021.10.011

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Research group:
Peter Medawar Building for Pathogen Research, NDM; Oxford University Hospitals NHS Foundation Trust
Role:
Author
ORCID:
0000-0002-2426-3097
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author

Contributors

Role:
Contributor
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Name:
National Institute for Health Research
Grant:
CL-2020-13-002
NIHR300791
Publisher:
Cell Press
Journal:
Cell More from this journal
Volume:
184
Issue:
23
Article number:
e11
Pages:
5699-5714
Publication date:
2021-10-16
Acceptance date:
2021-10-12
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
1206297
Local pid:
pubs:1206297
Deposit date:
2021-11-09

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