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Coarse-grained molecular dynamics simulations of the energetics of helix insertion into a lipid bilayer.

Abstract:

Experimental and computational studies have indicated that hydrophobicity plays a key role in driving the insertion of transmembrane alpha-helices into lipid bilayers. Molecular dynamics simulations allow exploration of the nature of the interactions of transmembrane alpha-helices with their lipid bilayer environment. In particular, coarse-grained simulations have considerable potential for studying many aspects of membrane proteins, ranging from their self-assembly to the relation between th...

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Publication status:
Published

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Publisher copy:
10.1021/bi800642m

Authors


Sansom, MS More by this author
Journal:
Biochemistry
Volume:
47
Issue:
43
Pages:
11321-11331
Publication date:
2008-10-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:faa1ca4f-4a98-4b16-968a-b77a92c01ab0
Source identifiers:
100612
Local pid:
pubs:100612

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