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An antigenic threshold for maintaining human immunodeficiency virus type 1-specific cytotoxic T lymphocytes.

Abstract:

BACKGROUND: Using the lymphocytic choriomeningitis virus (LCMV) model in mice, a number of studies show that memory cytotoxic T-lymphocyte (CTL) responses are maintained in the presence of continuous antigenic stimulation. Yet, other groups found that memory CTL specific for LCMV could last for a lifetime in mice without viral antigens. Thus, the extent to which an antigen is required for the maintenance of virus-specific CTL remains controversial. In humans, very few studies have been conduc...

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Publication status:
Published

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Authors


Bonhoeffer, S More by this author
Vesanen, M More by this author
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Journal:
Molecular medicine (Cambridge, Mass.)
Volume:
6
Issue:
9
Pages:
803-809
Publication date:
2000-09-05
EISSN:
1528-3658
ISSN:
1076-1551
URN:
uuid:fa97a436-404e-427d-aee3-cb5ab8ba25c7
Source identifiers:
102228
Local pid:
pubs:102228

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