An antigenic threshold for maintaining human immunodeficiency virus type 1-specific cytotoxic T lymphocytes.
BACKGROUND: Using the lymphocytic choriomeningitis virus (LCMV) model in mice, a number of studies show that memory cytotoxic T-lymphocyte (CTL) responses are maintained in the presence of continuous antigenic stimulation. Yet, other groups found that memory CTL specific for LCMV could last for a lifetime in mice without viral antigens. Thus, the extent to which an antigen is required for the maintenance of virus-specific CTL remains controversial. In humans, very few studies have been conduc...Expand abstract
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- Molecular medicine (Cambridge, Mass.)
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