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Thesis

Lysosomal dysfunction and glycosphingolipid dysregulation in rare and common neurodegenerative diseases

Abstract:

Historically, the rare early-onset neurodegenerative lysosomal storage disorders (LSDs) have been studied as discrete metabolic diseases in their own right. However, in recent years links with more common late-onset neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD), have emerged. For example, lysosomal dysfunction, impaired autophagy, and protein aggregation are shared features in these diseases. However, altered lipid homeostasis, ...

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Department:
Pharmacology
Role:
Author

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Department:
Pharmacology
Role:
Supervisor
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Grant:
H-1501
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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