Thesis
Lysosomal dysfunction and glycosphingolipid dysregulation in rare and common neurodegenerative diseases
- Abstract:
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Historically, the rare early-onset neurodegenerative lysosomal storage disorders (LSDs) have been studied as discrete metabolic diseases in their own right. However, in recent years links with more common late-onset neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD), have emerged. For example, lysosomal dysfunction, impaired autophagy, and protein aggregation are shared features in these diseases. However, altered lipid homeostasis, ...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:fa971c3c-9d2e-4a42-829a-3e724336c6ec
- Deposit date:
- 2019-07-01
Terms of use
- Copyright holder:
- Huebecker, M
- Copyright date:
- 2019
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