Thesis icon

Thesis

Backbone-modified oligonucleotides for biology and medicine

Abstract:

Chemically modified oligonucleotides find myriad applications in therapeutics and synthetic biology because they can be utilised to modulate biophysical or therapeutic properties, install fluorophores for detection, or to allow orthogonal reactivity through additional functional groups. Whilst oligonucleotides can be principally modified anywhere at their nucleotide subunits, the presented work investigates modifications of the oligonucleotide backbone for therapeutic applications and synt...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MPLS
Department:
Chemistry
Role:
Author

Contributors

Role:
Supervisor
More from this funder
Name:
Engineering and Physical Sciences Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000266
Funding agency for:
Epple, S
Grant:
EP/L015838/1
Programme:
EPSRC Centre for Doctoral Training in Synthesis for Biology and Medicine
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-03-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP