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Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity.

Abstract:

Signaling lymphocytic activating molecule ((SLAM) CDw150) is a glycoprotein that belongs to the CD2 subset of the immunoglobulin superfamily and is expressed on the surface of activated T- and B-cells. It has been proposed that SLAM is homophilic and required for bidirectional signaling during T- and B-cell activation. Previous work has suggested that the affinity of SLAM self-association might be unusually high, undermining the concept that protein interactions mediating transient cell-cell ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.M004117200

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
275
Issue:
36
Pages:
28100-28109
Publication date:
2000-09-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
11485

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