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Replacing, reducing and refining the use of animals in tuberculosis vaccine 1 research

Abstract:

Tuberculosis (TB) remains a serious global health threat and an improved vaccine is urgently needed. New candidate TB vaccines are tested using preclinical animal models such as mice, guinea pigs, cattle and non-human primates. Animals are routinely infected with virulent Mycobacterium tuberculosis (M.tb) in challenge experiments to evaluate protective efficacy, raising ethical issues regarding the procedure of infection itself, symptoms of disease and humane end-points. We summarise the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.14573/altex.1607281

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
McShane, H
Grant:
Senior Clinical Research Fellow
More from this funder
Name:
Universities Federation for Animal Welfare
Publisher:
ALTEX Edition
Journal:
ALTEX More from this journal
Volume:
34
Issue:
1
Pages:
157-166
Publication date:
2016-09-26
Acceptance date:
2016-09-22
DOI:
EISSN:
1868-8551
ISSN:
1868-596X
Keywords:
Pubs id:
pubs:646122
UUID:
uuid:fa8181e1-a38a-400e-b2a7-f03cc53e94a0
Local pid:
pubs:646122
Source identifiers:
646122
Deposit date:
2016-09-23

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