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A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.

Abstract:

Enzymes of the phosphodiesterase 3 (PDE3) and PDE4 families each regulate the activities of both protein kinases A (PKAs) and exchange proteins activated by cAMP (EPACs) in cells of the cardiovascular system. At present, the mechanisms that allow selected PDEs to individually regulate the activities of these two effectors are ill understood. The objective of this study was to determine how a specific PDE3 variant, namely PDE3B, interacts with and regulates EPAC1-based signaling in human arter...

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Publisher copy:
10.1074/jbc.m110.217026

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Journal:
Journal of biological chemistry More from this journal
Volume:
286
Issue:
18
Pages:
16285-16296
Publication date:
2011-05-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Language:
English
Keywords:
Pubs id:
pubs:237775
UUID:
uuid:fa7a00cb-fa88-4a38-9b43-ed68aea01e6c
Local pid:
pubs:237775
Source identifiers:
237775
Deposit date:
2012-12-19

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