Journal article icon

Journal article

TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation.

Abstract:

TSG-6 is an inflammation-induced protein that is produced at pathological sites, including arthritic joints. In animal models of arthritis, TSG-6 protects against joint damage; this has been attributed to its inhibitory effects on neutrophil migration and plasmin activity. Here we investigated whether TSG-6 can directly influence bone erosion. Our data reveal that TSG-6 inhibits RANKL-induced osteoclast differentiation/activation from human and murine precursor cells, where elevated dentine e...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m802138200

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of biological chemistry More from this journal
Volume:
283
Issue:
38
Pages:
25952-25962
Publication date:
2008-09-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Language:
English
Keywords:
Pubs id:
pubs:103887
UUID:
uuid:fa762c69-0546-4633-9601-474881181f4e
Local pid:
pubs:103887
Source identifiers:
103887
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP