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Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter.

Abstract:

Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by the absence of dystrophin. Utrophin is the autosomal homolog of dystrophin and capable of compensating for the absence of dystrophin, when overexpressed. In skeletal muscle, utrophin plays an important role in the formation of neuromuscular junctions. This selective enrichment occurs, in part by transcriptional regulation of the utrophin gene at the sub-synaptic nuclei in muscle. Utrophin's complex transcriptional re...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Journal of the neurological sciences More from this journal
Volume:
197
Issue:
1-2
Pages:
27-35
Publication date:
2002-05-01
DOI:
EISSN:
1878-5883
ISSN:
0022-510X

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