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The role of the p53 protein in the apoptotic response.

Abstract:

When mammalian cells or tissues are exposed to DNA damaging agents a programmed cell death pathway is induced as well as a cell cycle arrest. In mice in which the p53 gene has been inactivated by homologous recombination this response is profoundly diminished. These mice develop normally so that developmentally induced apoptotic events do not require p53. The p53 gene product is a 393 amino acid nuclear protein that binds specifically to DNA and can act as a positive transcription factor. Hig...

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Publication status:
Published

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Publisher copy:
10.1098/rstb.1994.0106

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
Volume:
345
Issue:
1313
Pages:
277-280
Publication date:
1994-08-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:fa6a716a-c323-4fc2-8b2d-2fc31332e40f
Source identifiers:
84078
Local pid:
pubs:84078

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