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The role of the p53 protein in the apoptotic response.

Abstract:

When mammalian cells or tissues are exposed to DNA damaging agents a programmed cell death pathway is induced as well as a cell cycle arrest. In mice in which the p53 gene has been inactivated by homologous recombination this response is profoundly diminished. These mice develop normally so that developmentally induced apoptotic events do not require p53. The p53 gene product is a 393 amino acid nuclear protein that binds specifically to DNA and can act as a positive transcription factor. Hig...

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Publication status:
Published

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Publisher copy:
10.1098/rstb.1994.0106

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Volume:
345
Issue:
1313
Pages:
277-280
Host title:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Publication date:
1994-08-01
Event location:
ENGLAND
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
Source identifiers:
84078
Keywords:
Pubs id:
pubs:84078
UUID:
uuid:fa6a716a-c323-4fc2-8b2d-2fc31332e40f
Local pid:
pubs:84078
Deposit date:
2012-12-19

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