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Regional thalamic MRI as a marker of widespread cortical pathology and progressive frontotemporal involvement in amyotrophic lateral sclerosis

Abstract:
Background The thalamus is a major neural hub, with selective connections to virtually all cortical regions of the brain. The multisystem neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) has pathogenic overlap with frontotemporal dementia, and objective in vivo markers of extra-motor pathological spread are lacking. To better consider the role of the thalamus in neurodegeneration, the present study assessed the integrity of the thalamus and its connectivity to m... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/jnnp-2018-318625

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0003-0267-3180
More from this funder
Name:
Motor Neurone Disease Association
Funding agency for:
Turner, MR
Grant:
Lady Edith Wolfson Senior Clinical Fellowship (MR/K01014X/1
More from this funder
Name:
Australian National Health and Medical Research Council
Funding agency for:
Tu, S
Grant:
CJ Martin Early Career Fellowship (APP1121859
More from this funder
Name:
Medical Research Council
Funding agency for:
Turner, MR
Grant:
Lady Edith Wolfson Senior Clinical Fellowship (MR/K01014X/1
Publisher:
BMJ Publishing Group
Journal:
Journal of Neurology, Neurosurgery and Psychiatry More from this journal
Volume:
89
Issue:
12
Pages:
1250-1258
Publication date:
2018-07-26
Acceptance date:
2018-07-09
DOI:
EISSN:
1468-330X
ISSN:
0022-305
Keywords:
Pubs id:
pubs:866873
UUID:
uuid:fa68165e-02e4-427d-9cee-f927e8aed8b1
Local pid:
pubs:866873
Source identifiers:
866873
Deposit date:
2018-07-10

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