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HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.

Abstract:

The multifunctional Nef protein of HIV-1 is important for the progression to AIDS. One action of Nef is to down-regulate surface MHC I molecules, helping infected cells to evade immunity. We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeostasis and is mutated in the iron-overloading disorder hemochromatosis. In model cell lines, Nef reroutes HFE to a perinuclear structure that overlaps the trans-Golgi network, causing a 90% reduction ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0504823102

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
31
Pages:
11017-11022
Publication date:
2005-08-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
49977

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