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Journal article

Mutational signature distribution varies with DNA replication timing and strand asymmetry

Abstract:
Background: DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures – each representing a mutagenic process – derived from 3056 patients spanning 19 cancer types to quantify the strand asymmetry of mutational signatures around replication origins and between early and late replicating regions. Results: We observe that most of the detected mu... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1186/s13059-018-1509-y

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Physiology, Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0002-8892-5133
More from this funder
Funding agency for:
Kriaucionis, S
More from this funder
Funding agency for:
Schuster-Boeckler, PB
Publisher:
BioMed Central Publisher's website
Journal:
Genome Biology Journal website
Volume:
129
Issue:
19
Publication date:
2018-09-10
Acceptance date:
2018-08-10
DOI:
EISSN:
1465-6906
ISSN:
1474-7596
Pubs id:
pubs:905036
URN:
uri:fa62920f-2e3d-47e9-af60-c73231d16d61
UUID:
uuid:fa62920f-2e3d-47e9-af60-c73231d16d61
Local pid:
pubs:905036

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