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Identification of contact residues in the IgE binding site of human FcεRIα

Abstract:

The high-affinity receptor for immunoglobulin E (IgE), FcεRI, is an αβγ2 tetramer found on mast cells, basophils, and several other types of immune effector cells. The interaction of IgE with the α-subunit of FcεRI is central to the pathogenesis of allergy. Detailed knowledge of the mode of interaction of FcεRI with IgE may facilitate the development of inhibitors for general use in the treatment of allergic disease. To this end we have performed site-directed mutagenesis on a soluble form of...

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Publisher copy:
10.1021/bi9713005

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Biochemistry More from this journal
Volume:
36
Issue:
50
Pages:
15579-15588
Publication date:
1997-12-16
DOI:
ISSN:
0006-2960
Language:
English
Pubs id:
pubs:171661
UUID:
uuid:fa6040de-2678-423e-bd14-a7b8d070d538
Local pid:
pubs:171661
Source identifiers:
171661
Deposit date:
2013-02-20

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