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Knotting probability of DNA molecules confined in restricted volumes: DNA knotting in phage capsids.

Abstract:

When linear double-stranded DNA is packed inside bacteriophage capsids, it becomes highly compacted. However, the phage is believed to be fully effective only if the DNA is not entangled. Nevertheless, when DNA is extracted from a tailless mutant of the P4 phage, DNA is found to be cyclic and knotted (probability of 0.95). The knot spectrum is very complex, and most of the knots have a large number of crossings. We quantified the frequency and crossing numbers of these knots and concluded tha...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.032095099

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
99
Issue:
8
Pages:
5373-5377
Publication date:
2002-04-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:154403
UUID:
uuid:fa53d5c1-b5be-480e-bb05-96d292251003
Local pid:
pubs:154403
Source identifiers:
154403
Deposit date:
2012-12-19

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