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Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine

Abstract:

The leading malaria vaccine in development is the circumsporozoite (CS) protein-based vaccine, RTS,S, which targets the pre-erythrocytic stage of Plasmodium falciparum infection. It induces modest levels of protective efficacy largely mediated by CS specific antibodies. We aimed to enhance vaccine efficacy by generating a potentially more immunogenic CS-based particle vaccine and developed a next-generation RTS,S-like vaccine, called R21. The major improvement is that in contrast to RTS,S, R2...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1038/srep46621

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Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Department:
Oxford, MSD, Colleges and Halls, Brasenose College
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Author
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Funding agency for:
Hill, AVS
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
46621
Publication date:
2017-04-05
Acceptance date:
2017-03-03
DOI:
ISSN:
2045-2322
Pubs id:
pubs:685488
URN:
uri:fa5080e4-b03e-4170-a0fd-4f2a626cd908
UUID:
uuid:fa5080e4-b03e-4170-a0fd-4f2a626cd908
Local pid:
pubs:685488

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