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Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria.

Abstract:

AIMS: To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. METHODS: Healthy volunteer data were obtained from six volunteers who received three different doses of HF (250, 500 and 1000 mg) after an overnight fast with a washout period of at least 6 weeks between doses. Patient data (n = 188) were obtained from randomised controlled trials conducted on the Thai-Burmese border in the early 19...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Journal of pharmacy and pharmacology More from this journal
Volume:
64
Issue:
11
Pages:
1603-1613
Publication date:
2012-11-01
DOI:
EISSN:
2042-7158
ISSN:
0022-3573

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