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Isolation and characterization of a MAGE gene family in the Xp21.3 region.

Abstract:

A human gene with strong homology to the MAGE gene family located in Xq27-qter has been isolated by using exon-trapping of cosmids in the Xp21.3 region. We have mapped and sequenced cDNA and genomic clones corresponding to this gene, MAGE-Xp, and shown that the last exon contains the open reading frame and is present in a minimum of five copies in a 30-kb interval. MAGE-Xp is expressed only in testis and, unlike the Xq27-qter MAGE genes, it is not expressed in any of 12 different tumor tissue...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.92.11.4987

Authors


Muscatelli, F More by this author
Walker, AP More by this author
De Plaen, E More by this author
Stafford, AN More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
92
Issue:
11
Pages:
4987-4991
Publication date:
1995-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:fa4077de-d291-4bae-b11c-961e769ea4d7
Source identifiers:
35694
Local pid:
pubs:35694

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