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Journal article

SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens.

Abstract:

Phagocytic and pathogen sensing receptors are responsible for particle uptake and inflammation. It is unclear how these receptors' systems influence each other's function to shape an innate response. The class-A scavenger receptors SR-A (scavenger receptor A) and MARCO (macrophage receptor with collagenous structure) are 2 well-characterized phagocytic receptors that are unable to initiate inflammatory responses by themselves, yet are implicated in the pathogenesis of various inflammatory dis...

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Publication status:
Published

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Journal:
Blood
Volume:
117
Issue:
4
Pages:
1319-1328
Publication date:
2011-01-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:fa3fa846-210d-4d0c-b2e1-5f631243d3fd
Source identifiers:
97281
Local pid:
pubs:97281

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