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HLA has strongest association with IgA nephropathy in genome-wide analysis.

Abstract:

Demographic and family studies support the existence of a genetic contribution to the pathogenesis of IgA nephropathy, but results from genetic association studies of candidate genes are inconsistent. To systematically survey common genetic variation in this disease, we performed a genome-wide analysis in a cohort of patients with IgA nephropathy selected from the UK Glomerulonephritis DNA Bank. We used two groups of controls: parents of affected individuals and previously genotyped, unaffect...

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Publication status:
Published

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Publisher copy:
10.1681/asn.2010010076

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
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Journal:
Journal of the American Society of Nephrology : JASN
Volume:
21
Issue:
10
Pages:
1791-1797
Publication date:
2010-10-05
DOI:
EISSN:
1533-3450
ISSN:
1046-6673
URN:
uuid:fa3f70e3-cafb-4d7d-bd81-38f9a274b687
Source identifiers:
74020
Local pid:
pubs:74020

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