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Journal article

Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial: blockade at the level of p21 is associated with short response duration.

Abstract:

PURPOSE: This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemotherapy. EXPERIMENTAL DESIGN: Cryopreserved blood mononuclear cells from 278 patients entering the LRF CLL4 trial comparing chlorambucil, fludarabine, and fludarabine plus cyclophosphamide were analyzed for ATM-p53-p21 pathway defects using an ex viv...

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Publication status:
Published

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Authors


Adamson, J More by this author
Johnson, GG More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
18
Issue:
15
Pages:
4191-4200
Publication date:
2012-08-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:fa396977-de80-4d72-8b14-c676cbb36581
Source identifiers:
341110
Local pid:
pubs:341110

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