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Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism

Abstract:

Synucleins are involved in multiple steps of the neurotransmitter turnover, but the largely normal synaptic function in young adult animals completely lacking synucleins suggests their roles are dispensable for execution of these processes. Instead, they may be utilized for boosting the efficiency of certain molecular mechanisms in presynaptic terminals, with a deficiency of synuclein proteins sensitizing to or exacerbating synaptic malfunction caused by accumulation of mild alterations, whic...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Role:
Author
ORCID:
0000-0002-6824-0663
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Name:
Wellcome Trust
Grant:
075615/Z/04/z
Publisher:
Elsevier
Journal:
Neurobiology of Aging More from this journal
Volume:
46
Pages:
107-112
Publication date:
2016-07-04
Acceptance date:
2016-06-25
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
Pmid:
27614017
Language:
English
Keywords:
Pubs id:
pubs:637437
UUID:
uuid:fa33a404-c4c6-4773-8e7f-cc31bc544b61
Local pid:
pubs:637437
Source identifiers:
637437
Deposit date:
2018-02-02

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