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The use of driving endonuclease genes to suppress mosquito vectors of malaria in temporally variable environments

Abstract:
Background The use of gene drive systems to manipulate populations of malaria vectors is currently being investigated as a method of malaria control. One potential system uses driving endonuclease genes (DEGs) to spread genes that impose a genetic load. Previously, models have shown that the introduction of DEG-bearing mosquitoes could suppress or even extinguish vector populations in spatially-heterogeneous environments which were constant over time. In this study, a stochas... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12936-018-2259-8

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
ORCID:
0000-0003-4274-4158
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
17
Issue:
1
Pages:
Article: 154
Publication date:
2018-04-04
Acceptance date:
2018-03-08
DOI:
ISSN:
1475-2875
Pubs id:
pubs:833973
URN:
uri:fa31c39e-a1a2-44e2-99c8-7521ba48f1e2
UUID:
uuid:fa31c39e-a1a2-44e2-99c8-7521ba48f1e2
Local pid:
pubs:833973

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