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Journal article

MAIT cells are activated during human viral infections

Abstract:

Mucosal Associated Invariant T (MAIT) cells are abundant in humans and recognise bacterial ligands. Here we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with Dengue virus, Hepatitis C virus, and Influenza Virus. This activation – driving cytokine release and Granzyme B upregulation - is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms11653

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More from this funder
Name:
Medical Research Council
Grant:
MR/K000241/1
STOP-HCV Consortium Funding
G0600371
More from this funder
Name:
Wellcome Trust
Grant:
PS2186_WMII
WT091663MA
More from this funder
Name:
National Institutes for Health Research
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Publication date:
2016-06-23
Acceptance date:
2016-04-07
DOI:
ISSN:
2041-1723
Pubs id:
pubs:617901
UUID:
uuid:fa2e35c1-9991-4207-a98c-ea10e7b08b8f
Local pid:
pubs:617901
Source identifiers:
617901
Deposit date:
2016-04-26

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