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MAIT cells are activated during human viral infections

Abstract:

Mucosal Associated Invariant T (MAIT) cells are abundant in humans and recognise bacterial ligands. Here we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with Dengue virus, Hepatitis C virus, and Influenza Virus. This activation – driving cytokine release and Granzyme B upregulation - is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cel...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms11653

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Institution:
University of Oxford
Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
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Institution:
University of Oxford
Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
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National Institutes for Health Research More from this funder
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Grant:
WT091663MA; PS2186_WMII
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Grant:
STOP-HCV Consortium Funding; MR/K000241/1; G0600371
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Publication date:
2016-06-23
DOI:
ISSN:
2041-1723
URN:
uuid:fa2e35c1-9991-4207-a98c-ea10e7b08b8f
Source identifiers:
617901
Local pid:
pubs:617901

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