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Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression

Abstract:

Inosine pranobex (IP) is a synthetic immunomodulating compound, indicated for use in the treatment of human papillomavirus‐associated warts and subacute sclerosing panencephalitis. Previous studies demonstrate that the immunomodulatory activity of IP is characterized by enhanced lymphocyte proliferation, cytokine production, and NK cell cytotoxicity. The activation of NKG2D signalling on NK cells, CD8+ T cells and γδ T cells also produces these outcomes. We hypothesized that IP alters cellula...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.201847948

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Institution:
University of Oxford
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
ORCID:
0000-0001-9962-3248
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Name:
Medical Research Council
Grant:
G0901998
Publisher:
Wiley
Journal:
European Journal of Immunology More from this journal
Volume:
50
Issue:
1
Pages:
130-137
Publication date:
2019-08-21
Acceptance date:
2019-08-20
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Language:
English
Keywords:
Pubs id:
pubs:1046478
UUID:
uuid:fa2260ad-5390-48ab-a29e-1a02126ae6aa
Local pid:
pubs:1046478
Source identifiers:
1046478
Deposit date:
2019-08-20

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