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Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study.

Abstract:

BACKGROUND: Hypertension can be controlled adequately with existing drugs such as angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. Nevertheless, treatment success is often restricted by patients not adhering to treatment. Immunisation against angiotensin II could solve this problem. We investigated the safety and efficacy of CYT006-AngQb-a vaccine based on a virus-like particle-that targets angiotensin II to reduce ambulatory blood pressure. METHODS: In this mult...

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Journal:
Lancet
Volume:
371
Issue:
9615
Pages:
821-827
Publication date:
2008-03-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:fa13494a-b154-42e2-a793-25fa0e7a06d4
Source identifiers:
422419
Local pid:
pubs:422419

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