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Effects of glucocorticoids on fat mass and the therapeutic potential of targeting II beta-hydroxysteroid dehydrogenase type I in obesity

Abstract:

The epidemic of obesity and Type 2 diabetes has driven the need for novel and efficacious treatments. Based upon parallels in patients with glucocorticoid excess or Cushing's syndrome, glucocorticoid action has emerged as a novel target for therapy. In the vast majority of obese patients and those with Type 2 diabetes, circulating cortisol levels are not elevated. However, within key metabolic target tissues, the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts the inactive ...

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Publication status:
Published

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Publisher copy:
10.2217/CLP.09.31

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Journal:
CLINICAL LIPIDOLOGY
Volume:
4
Issue:
4
Pages:
439-447
Publication date:
2009-08-05
DOI:
ISSN:
1758-4299
URN:
uuid:f9ff4293-6eba-4749-8710-98e698af5e8d
Source identifiers:
482132
Local pid:
pubs:482132

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